Endocrine Abstracts

Sex is an important parameter that influences biology and physiology of almost every organ. Sex bias is not restricted to homeostatic conditions, but is also evident in the predisposition and progression of diseases. The adrenal cortex, in particular, displays dramatic sex differences and the majority of adrenocortical diseases occur more frequently in women than in men. Understanding how sex hormones affect biology on the molecular level has therefore become an important focu...

Adrenal insufficiency is a life-threatening condition in which the adrenal glands fail to produce adequate amounts of steroid hormones thus leading to severe disturbances of body homeostasis. Today’s treatment options are limited to hormone replacement therapies that are, however, hampered by serious side effects. Cell replacement therapies with adrenocortical stem cells could present a potential cure, but the culture of such stem cells has proven difficult. We have devel...

The adrenal cortex, a pivotal endocrine regulator governing body homeostasis, metabolism, and stress response through steroid hormone synthesis, presents formidable challenges for effective replacement in disorders like adrenal insufficiency and congenital adrenal hyperplasia. The limitations of current hormone replacement strategies stem from the intricate dynamics of hormonal release. This study harnesses insights derived from the analysis of a recently published single-cell...